Most women in menopause are focused on the wrong cancer.
Colorectal cancer is now the number one cause of cancer death in adults under 55 — and rates are rising 3% every year in people aged 20 to 49. For midlife women navigating perimenopause and post-menopause, the risk window is right now. And almost nobody is connecting these dots.
In this episode of the Health Trip Podcast, Jill Foos sits down with Dr. Faris Murad — board-certified gastroenterologist, Mayo Clinic-trained, and founder of Santé Integrated Health & Wellness on Chicago's North Shore — for one of the most important and overlooked conversations in women's midlife health.
What menopause actually does to your gut, your colon, and your microbiome. Why the GI symptoms you've been experiencing since perimenopause started are not in your head. What a polyp actually is and what it means when one is found during screening. Why the colonoscopy prep is no longer the barrier it used to be. And the data point that will genuinely stop you — the Women's Health Initiative found a 37% reduction in colorectal cancer risk among women on combined hormone therapy. This benefit is almost never part of the HRT conversation. It should be.
Dr. Murad breaks down the estrobolome — the gut's hidden estrogen-metabolizing system — and explains why it becomes dysregulated in menopause, compounding hormonal decline and driving symptoms most women attribute to aging. He explains the full landscape of colorectal cancer screening options beyond colonoscopy, including FIT tests, Cologuard, and virtual colonoscopy, and walks through modern prep options that make the experience significantly more tolerable than most women expect.
He also addresses the data connecting hormone replacement therapy to meaningful colon cancer risk reduction — evidence that most clinicians and patients have never discussed — and explains why midlife women with the highest genetic risk may benefit the most from HRT's protective effect on the colon.
This is the episode that makes you schedule the screening you have been putting off. Early detection is almost always curative. Waiting for symptoms is not a strategy.
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